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The 8th FEBS Advanced Lecture Course “Matrix Pathobiology, Signaling and Molecular Targets”, will cover topics related to ongoing development in the fields of:
- Cell surface, interactions and signaling dealing with integrins, cell membrane and secreted proteoglycans as well as shed syndecans and glypicans, modulation of receptor activation and signaling by matrix effectors,
- Matrix remodeling enzymes dealing with enzymes (MMPs, cathepsins, heparanase, hyaluronidases) implicated in disease development and progression,
- Matrix organization and assembly dealing with novel collagen types, matrikines and other emerging concepts including proteoglycans & GAGs, non-collagenous proteins, matrix components and inflammation as well as tissue organization and properties.
- Novel insights in matrix pathobiology regulatory mechanisms dealing with epigenetic modifications (including microRNAs) regulating assembly and functions of ECM macromolecules, cell-matrix interactions with focus on pharmacological targeting of cancer.
The above fields will also focus on matrix-mediated epithelial to mesenchymal transition (EMT), glycomics and domain mapping of interactions with matrix effectors and their importance for disease treatment and diagnosis. Key areas of cancer stem cell biology and biomarkers, and pharmacological targeting in malignancies are also included.
This FEBS ALC course will provide important new knowledge to participants in the form of:
- Understanding the importance of the main matrix macromolecules, their structure-function relationship as well as their therapeutically challenges, mainly from the general lectures (tutorials) to be held.
- The tissue organization and the matrix assembly mediated by matrix macromolecules in health and disease.
- New insights on how matrix macromolecules contribute to matrix-mediated cell signaling and cell behavior as well as how these molecules affect disease development and progress.
- Participants will further become familiar with methodological challenges used for expression and determination of various macromolecules with biopharmaceutical importance as well as novel aspects of cell imaging.
An important goal of this ALC is to bring together scientists from biochemistry, life sciences, molecular cell biology and bioinformatics on an important and fast-growing scientific field. The benefits of the course will provide participants with the advances of the field, a new understanding of the matrix-mediated cell regulation, new technology for unraveling molecular structures and functions, as well as how this can be used to study alterations in tissue in disease. The participants will gain information that can be applied in their academic environment and research institutes. For such a purpose apart from invited lectures and tutorials, selected talks and flash presentations from young fellows, poster sessions, panel discussions and speaker corners (meet the experts) will be organized.