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Life sciences have recently increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell migration, adhesion and signaling. Upon interactions in the extracellular space, these macromolecules affect the extracellular matrix (ECM) dynamics and via cell receptors communicate with the cellular compartment. Emerging areas of research in the ECM field include epigenetic regulation of matrix macromolecules, microRNAs, stem cell biology, as well as the development of novel molecular modeling methodologies. Knowledge of these aspects will deepen our understanding of ECM regulatory roles in pathophysiology and inform the design of new pharmacological agents targeting serious diseases including, among others, cancer, angiogenesis, fibrosis, immunity and infectious diseases.Issues related with matrix organization and assembly, cell adhesion, matrix-mediated signaling, as well as the matrix macromolecular effectors, namely proteoglycans and glycans, integrins, novel collagen types, growth factors and matrix metalloproteinases and other matrix degrading enzymes that affect the cell behavior, will be the target of this 8th FEBS-ALC "Matrix Pathobiology, Signaling and Molecular Targets". These topics are of great importance to understand the maintenance of normal tissue homeostasis and disease initiation and development, signaling elicited by interactions of cell surface receptors with matrix components and growth factors and rapid and sensitive structure analysis, epigenetics and cell imaging methods.
Following the 2015, 2017 and 2019 very successful set-up of FEBS-MPST series, as well as the 2018 FEBS-ECM, a young scientists’ committee will organize general lectures/tutorials in the first day of the meeting as well as pubquiz during the entire course providing in this way the necessary brainstorming for those entering the field of Extracellular Matrix Pathobiology. A career development session to promote the motivation of students including general presentations/tutorials will be also organized by the young scientists’ committee.